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pentobarbital will lower the level or impact of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Potent or average CYP3A4 inducers noticeably minimize guanfacine plasma concentrations and elimination 50 percent-lifestyle.pentobarbital will minimize the extent or effect of buprenorphine subderma